He is the younger brother of current Cleveland Browns special teams coordinator Ray Ventrone.

After graduating from high school, Ventrone began his college career as a walk-on at the University of Pittsburgh.

In 2007, Ventrone transferred to Villanova University, his brother Ray's alma mater, where he earned a football scholarship.

As a junior in 2008, Ventrone led the team with four interceptions, along with 61 tackles and a fumble recovery in 13 games played.

Ventrone was signed, promoted, or released 21 times by the Patriots during the season, including eight transactions in November 2011.

The Patriots signed, promoted, or released him 29 times;[3] an ESPN article compared Ventrone to a "human yo-yo.

On August 14, 2016, the Steelers placed Ventrone on injured reserve after suffering a hamstring injury against the Detroit Lions.