Route 114 was a major north–south artery for its entire length until the arrival of the Interstate Highway System.

Route 114 heads north on West Main Road in Middletown and Portsmouth.

In Bristol, it continues north along Ferry Road then shifts to Hope Street.

Pawtucket Avenue continues north through downtown East Providence, crossing over I-195, where it is joined by US 1A.

After running through several Pawtucket city streets, including an interchange with I-95, Route 114 crosses the Blackstone River and continues north along Broad Street into the city of Central Falls.

[a] After crossing the Blackstone River into the town of Cumberland, Route 114 shifts one block east to High Street as it heads towards the village of Valley Falls.

[c] Two sections of modern Route 114 were previously laid out as turnpikes in the early 19th century.