It crosses Route 443 to the Tel Aviv area and Highway 45 to Atarot and ends at the Beitunia section of the security barrier.

The road begins at the heavily congested intersection of Route 417 (Bar-Ilan Street/Hativat HarEl Boulevard) and Shmuel HaNavi Street.

It passes Jerusalem's largest high tech park, Har Hotzvim, while descending into Emek HaArazim (Valley of The Cedars) at 630 meters.

Leaving Ramot and the Jerusalem Municipality, the road becomes four lanes wide, passing the entrance to Nebi Samuel and reaching an altitude of 840 meters.

North of 443/45, the road provides entrances to Mahane Ofer and the Beitunia cargo transfer terminal, officially ending as numbered.