Service operated every 15 minutes during rush hour only.

Unlike a local bus, the 46 did not stop at every bus stop along its route; rather, its stops were limited to certain locations of importance, including transfer points to other bus lines, major landmarks, and other busy intersections selected by MTA.

46 designation has previously been used for several other streetcars and buses in the Baltimore area.

These included a shuttle that operated briefly in the Woodberry area that resembles part of the present Route 98 as a streetcar 1901-49 and as a bus 1949-70, and a series of routes for the Baltimore City Public Schools that operated 1999-2003.

[3] When the revamped BaltimoreLink bus system began operating, the 46 went out of service.