[1] It connects Montevideo with the northeast of Rivera Department, at Vichadero, with an extension reaching the border with Brazil.

The road is approximately 428 kilometres long till Vichadero.

The distance notation along Route 6 uses the same Kilometre Zero reference as Routes 1, 3, 5, 7, 8, 9 and IB, which is the Pillar of Peace of Plaza de Cagancha in the Centro of Montevideo.

North of Canelones, Route 6 passes mostly through sparsely populated areas and connects with few small towns and villages.

These are the populated places Route 6 passes through, as well as its main junctions with other National Roads.