San Gregorio de Polanco is a small city in the Tacuarembó Department of northern-central Uruguay.

The city is located on a peninsula on the north shore of the artificial Rincón del Bonete Lake and along Route 43, about 140 kilometres (87 mi) south of the department capital city of Tacuarembó.

Route 43 passes across the lake to Durazno Department by ferryboat.

[1] On 13 October 1963, its status was elevated to "Villa" (town) by the Act of Ley Nº 13.167,[2] and then on 13 December 1994 to "Ciudad" (city) by the Act of Ley Nº 16.666.

[3] In 1945, the artificial lake of Rincon del Bonete hugely changed the landscape of this town, adding a water surface and, later, beaches.