It serves the MBTA Orange Line, and is located on Tremont Street in the Mission Hill neighborhood.

Starting in 1891, the Old Colony Railroad (which had acquired the B&P in 1888, and was itself acquired in 1893 by the New York, New Haven and Hartford Railroad) raised the section of its main line through Roxbury and Jamaica Plain (extending from Massachusetts Avenue to the current location of Forest Hills station) onto a 4-track stone embankment to eliminate dangerous grade crossings.

[2] Although the five NYNH&H stations in Roxbury and Jamaica Plain continued to operate for over three decades following the southward extension of the Washington Street Elevated, they were ultimately unable to compete with the Elevated, and Roxbury Crossing, along with the other four stations, was closed on September 29, 1940 due to a lack of passengers.

[4][7] In the 1960s, plans took hold to extend I-95 into downtown Boston along the NYNH&H's right-of-way and to replace the Washington Street Elevated (from 1967 known as the Orange Line) with a rapid transit line running in the new highway's median; these plans led to the demolition of hundreds of homes (including the virtual obliteration of the Roxbury Crossing neighbourhood) and the clearing of a long strip of land (the Southwest Corridor) extending through Roxbury and Jamaica Plain all the way up to Green Street, before the project was halted by highway revolts in 1969 and the February 11, 1970 announcement by Governor Francis W. Sargent of a moratorium on new highway construction within the Route 128 corridor, and eventually cancelled by Governor Sargent in 1972.

The entire Orange Line, including Roxbury Crossing station, was closed from August 19 to September 18, 2022, during maintenance work.