It is managed by the Aneurin Bevan University Health Board.

The Royal Gwent hospital has a 24-hour Minor Injuries Unit.

[2] It moved to a site in Cardiff Road donated by Viscount Tredegar in the early 20th century: it was officially opened there by Viscount Tredegar as the Newport and Monmouthshire Hospital in August 1901.

[4] The hospital joined the National Health Service in 1948: it was then completely reconstructed to create modern facilities in the early 1960s.

[5] During the COVID-19 pandemic, it was reported that around half of A&E medical staff had tested positive for coronavirus.