Since 2013, O'Donnell has portrayed the role of Peri Lomax in the Channel 4 soap opera Hollyoaks.

[5] In July 2024, O'Donnell confirmed that she was dating her Hollyoaks co-star Nathaniel Dass.

[9] On the storyline, O'Donnell said "Some of the scenes have been hard to tackle because I am still quite young and I've had to do a lot of research for them.

[12] In August 2017, O'Donnell was longlisted for Best Young Actor at the Inside Soap Awards,[13] however she did not progress to the shortlist.

[15] O'Donnell's character has since developed a relationship with Juliet Nightingale (Niamh Blackshaw), for which the pair received a nomination for Best Soap Partnership at the I Talk Telly Awards.