Johnny Vegas and Emma Frain have also featured in multiple sketches between clips on episodes hosted by Alex Zane.

[citation needed] Rude Tube was first broadcast on Channel 4 as a pilot episode on 6 February 2008, presented by Alex Zane.

A special episode entitled Rude Tube 2009 was broadcast on Channel 4 on 2 January 2009, with Alex Zane returning as host.

Rude Tube 2009 featured the "top 50 viral video clips on the web" as rated by number of views in 2008.

A second series, known as Rude Tube III was broadcast on Channel 4 in October 2009 and featured three new 60-minute episodes.

A third series, Rude Tube IV commenced in October 2010 and ran for 6 episodes, followed by the third New Year special, broadcast on 7 January 2011.

A fourth full series of the show featured eight new episodes and aired on Channel 4 from September to November 2011.

Comedian Johnny Vegas guest starred with Zane as the voice of the "talking computer" on some of the 2012 and 2013 episodes.

In addition, two special programmes, Rude Tube Christmas Cracker 2014 and Welcome to 2015 were shown on Channel 4 on 25 December 2014 and 1 January 2015 respectively.