Rodolfo Mancuso grew up in Glen Ridge, New Jersey, the son of an Italian-American father and a Portuguese-Brazilian mother, along with a sister, Marianna.

He was the opener for Justin Bieber's Purpose World Tour in Brazil's section of his Latin America shows in 2017.

[13] Dolce & Gabbana invited Mancuso to walk in their Milan Men's Fashion Week Spring/Summer 2018 show on June 17, 2017.

[22] Mancuso collaborated with fellow comedian and musician Simon Rex for the video "Storytelling" which was released on his channel July 2018.

[24] He and fellow Shots Studios artist Lele Pons hosted the 2018 Hispanic Heritage Foundation Awards show.

[27] He also performed a cover of Queen's You're My Best Friend in support of Netflix's Bohemian Rhapsody (film) and the Mercury Phoenix Trust which was released to his YouTube channel.

[28] He also hosted the 'Concert for Tommy's Field', a charity event held at the Orpheum Theater in Los Angeles.

Mancuso has produced sponsored videos working with companies such as Target and Clif bar which blend music and comedy.