[18] Shots Studios channels have tens of millions of followers combined, tapping into an increasingly digital world with online comedy, music, and other video content.

Shots Studios creators have partnered with companies such as Google, Target, Tarte Cosmetics, AXE, EA Sports, Budweiser, COVERGIRL, and many others to produce branded content.

[19][20] In 2016, Shots Studios partnered with Mike Tyson to launch a YouTube channel for the boxer to share sketch comedy on.

[21] The company began to manage other creators, assembling a roster of Rudy Mancuso, Lele Pons, Anwar Jibawi, Hannah Stocking and Jake Paul,[22] in order to produce content on their own YouTube channels.

Shots Studios previously partnered and collaborated with other entertainers such as Alesso, Anitta, Marlon Wayans, Mike Tyson, Inanna Sarkis, and Loren Gray.

[26] On September 3, Anitta released her first English-language single, a collaboration with Grammy Award-winning producer and songwriter Poo Bear titled "Will I See You."

[30][31][32][33] In September 2017, Alesso and American artist Hailee Steinfeld released "Let Me Go" featuring Florida Georgia Line and Watt.

In July 2018, Variety announced that Shots Studios partnered with Netflix to produce a six-episode docuseries that followed the life of Brazilian pop star Anitta.

"[36] John and Sam Shahidi were named to Billboard's Latin Power Players list for their and their artists' success in the Spanish-speaking market in November 2018.

[37] In late November 2018, Alesso released "Tilted Towers," a collaborative project with Fortnite streamer and YouTuber Ninja, which debuted live on the gamer's Twitch stream.

Shots Studios’ slate of programs was headlined by projects from Rudy Mancuso, Juanpa Zurita and Lele Pons.

[43] On April 22, 2020, Variety announced Shots Studios’ YouTube Original docuseries titled The Secret Life of Lele Pons.

On August 24, Tubefilter announced that Shots Studios had entered a new partnership with NRG Esports for content production, social strategy, and apparel.