Brown, an American physician and computer scientist, is the inventor[1] of the N-localizer[2] technology that enables guidance of stereotactic surgery or radiosurgery using medical images that are obtained via computed tomography (CT),[3] magnetic resonance imaging (MRI),[4] or positron emission tomography (PET).
[5] Brown invented the N-localizer in 1978 when he was a medical student[6] investigating image-guided surgery in the laboratory of his mentor, James A. Nelson, at the University of Utah.
A few months later, Brown designed and built the first CT-compatible stereotactic frame in order to test the concept of the N-localizer.
[7] Brown also made contributions to the k-d tree[8] and to the generalized Born model[9] of implicit solvation.
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