Cassata speaks at high schools and universities on the subject of gender dysphoria, being transgender, bullying and his personal transition from female to male, including top surgery in January 2012, when he was 18 years old.

[11] Songs for Alexis, produced by Copenhagen Bombay with help from the Danish Film Institute, had its world premiere at Hot Docs Canadian International Documentary Festival to a sold-out crowd on April 30, 2014.

[16] Since 2007, Ryan Cassata has presented at high schools, universities, support groups and conferences on topics such as coming out, gender dysphoria, being transgender, sex reassignment surgery, and bullying.

Cassata talks about the petitions he made in Bay Shore High School to advocate for the rights of transgender students.

His 2012 music video, "Hands of Hate" released on YouTube honors and remembers LGBT Youth who were murdered or committed suicide.

Larry King is honored in the second verse:And Lawrence King never saw ninth grade, Before that bullet was forced into his brain,By a bully, a madman, A classmate of rage.Just at fifteen, young Larry was sent to his grave.Ryan Cassata raised money with the Frank Cassata Family Foundation and Underworks in 2014 to provide over 400 transgender youth with new chest binders.

"[26] Cassata has appeared on Larry King Live, The Tyra Banks Show and local television to speak about being transgender.

[30][31] Cassata is the first openly transgender musician to perform at Warped Tour after winning the Ernie Ball Battle of The Bands contest in 2013 and 2015.

[34] Cassata is one of two of the 2019 recipients of The ASCAP Foundation "Sunlight of the Spirit" Award which is presented to an individual who is exemplary in recovery and in music creativity for his original song "Jupiter."

[36] Ryan Cassata has collaborated on videos with Davey Wavey,[37] Skylar Kergil, Aydian Dowling, ElloSteph, Arielle Scarcella, Marissa Farina, and Stevie Boebi.

Cassata became the first transgender person on the LGBT Panel at Playlist Live in February 2015 and appeared with Stevie Boebi, ElloSteph, Marissa Farina, RJ Aguiar, and Tyler Oakley.

[41] Cassata appeared in a Bonobos (apparel) national commercial titled "However You Fit" in 2018 which featured 172 men wearing the same style of pants.