He played college football at Florida State, and was selected by the New England Patriots in the 2018 NFL draft.

Initially, he drew little attention from NCAA Division I football programs until Virginia Tech expressed interest and 20 other schools followed thereafter before he graduated in 2014.

[2] As a redshirt freshman in 2015, Izzo played in all 13 of Florida State's games, catching 14 passes for 210 yards and two touchdowns.

[14] Izzo became the 73rd different player to catch a touchdown pass from Tom Brady, scoring on a 10-yard play in the Patriots' week 5 33–7 victory over the Washington Redskins.

[16] On March 18, 2021, Izzo was traded to the Houston Texans for a seventh round pick in the 2022 NFL draft.

[26] On January 5, 2023, Izzo signed with the Philadelphia Stars of the United States Football League (USFL).

[27] The Stars folded when the XFL and USFL merged to create the United Football League (UFL).