He played college football at the University of Miami and signed with the Houston Texans as an undrafted free agent in 2016.
[1] After being born in California, Kamalu spent the first 13 years of his life in Aba, Nigeria with his siblings, while his parents stayed back home.
It has been reported that by his father's request he began playing football his freshman year of high school.
[11] He made his professional debut in Week 13 in a start against the Green Bay Packers, where he recorded his first career tackle in a 21–13 loss.
[12] Kamalu recorded his first career sack on Matt Cassel in a Week 17 loss to the Tennessee Titans.
Benjamin Herbst allegedly called the young lady in question to bail Ufomba Kamalu out of jail, but she was afraid and did not want to do so.
[29] Despite his alleged history with domestic violence, Kamalu managed to signed with the BC Lions of the CFL on December 30, 2020.