Nassib was named as Syracuse's new starting quarterback during 2009 spring practices, jumping over Dantley and Andrew Robinson.

[1] After just one week of fall practice, however, head coach Doug Marrone named Duke transfer Greg Paulus as the team's 2009 starter.

[3] With the departure of Paulus, Ryan moved up the depth chart as he became the starter for the Orange for the 2010 season.

At Akron, Nassib led Syracuse to its first season-opening victory since 2003 as he threw for 229 yards and two touchdowns on 17 of 27 completions.

Nassib piloted a 98-yard scoring drive in the fourth quarter and a three-yard touchdown completion to Marcus Sales to win the game against South Florida.

Down 15 points in the season opener against Wake Forest, Nassib led the Orange to a comeback win in overtime with a 4-yard touchdown pass to Van Chew.

Nassib earned Big East Weekly Honor Roll recognition with a 25 for 37, 230 yard, one touchdown performance against USC.

Nassib was once again named to the Big East Weekly Honor Roll against Toledo as he completed 16 of 24 passes for 213 yards and two touchdowns in an overtime victory.

[citation needed] Source: [4] Nassib was selected with the 110th overall pick in the fourth round of the 2013 NFL draft by the New York Giants.

[9] On December 27, 2015, in a 49–17 loss to the Minnesota Vikings, Nassib threw his first NFL touchdown pass to wide receiver Myles White in the fourth quarter.