He started 34 games in his career, and earned All-Big East Conference honors in three consecutive seasons; second-team as a sophomore, and first-team as a junior and senior.

[8] Throughout training camp, Pugh competed with incumbent starter David Diehl for the starting right tackle position.

[9] Head coach Tom Coughlin named Pugh the starting right tackle to begin his rookie season.

He made his first career start and professional regular season debut in the Giants' season-opening 36–31 loss at the Dallas Cowboys.

He started 14 games at right tackle and missed weeks 12-13 after suffering a quad injury that plagued him for a part of the season.

[15] By the end of the season he was ranked the ninth best offensive guard by Pro Football Focus with an overall grade of 86.7.

[16] On April 26, 2016, the New York Giants chose to pick up the fifth-year, $8.82 million option on Pugh's rookie contract.

Through the first nine games, he was ranked as the top offensive left guard in the league by Pro Football Focus with an overall grade of 87.8.

[28] In February 2015, Pugh appeared as a contestant on a celebrity edition of Who Wants to Be a Millionaire?, winning $10,000 for Shriners Hospitals for Children.