[4] Panchadsaram earned a bachelor's degree in Industrial Engineering and Operations Research from the University of California, Berkeley.

Prior to joining the federal government, Panchadsaram was responsible for Customer Development at Ginger.io, a spin-off from MIT Media Lab, a health industry big data company.

[6] In 2021, Panchadsaram co-authored the book Speed & Scale: An Action Plan for Solving Our Climate Crisis Now with Kleiner Perkins chairman John Doerr.

As U.S. Deputy Chief Technology Officer, Panchadsaram worked on President Obama's Smarter IT Delivery Initiative,[9] including the Smarter IT Delivery Cross-Agency Priority Goal,[10] the U.S. Digital Services Playbook,[11] and the creation of the United States Digital Service.

Panchadsaram was also part of the team that launched and expanded adoption of Blue Button, the concept of and technology for patients to access their own health records in a structured, computable manner.