São Roque is a civil parish in the northern part of the municipality of Funchal, on the island of Madeira.

This was instituted with its parish seat at the ancient chapel of São Roque, constructed by the residents at the beginning of the 16th century, probably from local funds collected by Funchal's citizens (Saint Roch was the patron saint of Funchal protecting them from the plague, during the early part of the 16th century).

A newer church, directed by master António Vila Vicêncio, was later erected; its main construction continued until 1820, but was finally completed in the middle of the 19th century.

This includes several of its localities, which were formed from rural concentrations, and developed into residential boroughs by the 20th century: Achada, Muro da Coelha, Conceição, Fundoa, Igreja Velha, Calhau, Igreja Nova, Alegria, Bugiaria, Lombo Segundo, Lombo de São João and Santana.

Until the mid-20th century, the region was primarily agricultural, but the southern limits of the parish have now been developed extensively towards the foothills of the central mountain range.