In August 2017, she began hosting S. E. Cupp: Unfiltered, a political panel show, co-hosted by Andrew Levy, on HLN and later CNN.

She is a former panelist on the CNN political debate show Crossfire, author of Losing Our Religion: The Liberal Media's Attack on Christianity and co-author of Why You're Wrong About the Right.

[10] After living and working in New York City for over a decade, Cupp moved to Washington, D.C., in 2013, after CNN hired her to join the panel of a new version of Crossfire, with panelists Newt Gingrich, Stephanie Cutter, and Van Jones.[11][12][timeframe?]

[15] She began hosting a political show leading up to the 2024 United States presidential election, called Battleground, on Fox in 2024.

When asked to explain, Cupp said she felt that a president must not represent only 10 to 15 percent of the American populace and that faith served as a "check" on presidential power.

[22] During Ron Paul's 2012 presidential campaign, Cupp criticized his non-interventionist foreign policy, saying the United States has an obligation to "[fight] brutal regimes and human rights abuses around the world".

[25] Since 1995, Cupp has been an atheist, but has consistently stated that she is open to theism,[26][27][28] and once said in an interview with C-SPAN, "I really aspire to be a person of faith some day.

"[29] Cupp met John Goodwin, a former chief of staff to Representative Raúl Labrador, at the 2008 Republican Convention, and they began dating in 2011.