The original plan to rebuild the church was designed by Jacopo Sansovino, who fled the city during the Sack and never returned to finish it.

The work was continued by Antonio da Sangallo the Younger, who rebuilt the church, but a Tiber flood damaged it again in 1530.

[1] The exterior travertine statues were sculpted by Francesco Cavallini, and the stucco bas-relief over the entrance, with depicts San Filippo Benizio, was created by Antonio Raggi.

Under the main altar, decorated with 12th century opus sectile, are the relics of several saints, which include those of Pope Marcellus as well as Digna and Emerita.

The first chapel on the left has the double tomb of Cardinal Giovanni Michiel and his grandson Antonio Orso sculpted by Jacopo Sansovino.

Inside is a cyborium (1691) designed by Carlo Bizzaccheri; in the fifth chapel is a monument to the Cardinal Fabrizio Paolucci (1726) by Pietro Bracci with an altarpiece by Aureliano Milani and lateral paintings by Domenico Corvi; and a monument to cardinal Camillo Paolucci by Tommaso Righi (1776) and wall paintings by Aureliano Milani.