SAM-IV riboswitches are a kind of riboswitch that specifically binds S-adenosylmethionine (SAM),[1] a cofactor used in many methylation reactions.

Originally identified by bioinformatics,[2] SAM-IV riboswitches are largely confined to the Actinomycetales, an order of Bacteria.

Conserved features of SAM-IV riboswitch and experiments imply that they probably share a similar SAM-binding site to another class of SAM-binding riboswitches called SAM-I riboswitches.

The structural relationship between these riboswitch types has been studied.

This molecular or cell biology article is a stub.