The highway connects the Anderson and Laurens areas with Honea Path and Ware Shoals.

It travels to the east-southeast and crosses Neals Creek before an intersection with SC 413.

The highway begins curving to the southeast and crosses over Hencoop Creek before entering Craytonville.

Then, the highway starts traveling to the east-northeast and crosses Blue Barker Creek, just before entering Honea Path.

[7] Through town, it travels just south of Honea Path Middle School before it has a second intersection with US 76/US 178 (North Main Street).

Just after leaving town, SC 252 enters Abbeville County and travels through Broadmouth.

They cross over the Saluda River on the Senator William H. "Billy" O'Dell Bridge, which marks the Laurens County line.

A short distance later, it meets its eastern terminus, an intersection with US 76 (West Main Street).

and SC 252 Truck travel concurrently on South Greenwood Avenue.

The concurrency curves to the north-northwest and reach an interchange with the northern terminus of US 25 Bus.