[7] The entire section of US 25 along Corridor W boasts a four-to-six-lane limited-access road, with interchanges at major intersections.

By 1961, US 25 was moved onto a new bypass east of North Augusta, leaving US 25 Business (US 25 Bus.).

In 1964, US 25 was rerouted onto new primary routing east of Travelers Rest, leaving Main Street to US 276 and Poinsett Highway downgraded to secondary (today now an unsigned US 25 Connector).

In 1973, US 25 was rerouted in northern Greenville County onto new modern ascent along the Saluda Mountains; the old route was downgraded to secondary (Old Highway 25/S-23-969).

By the end of 1926, the path of the highway between Edgefield and Kirksey was rerouted, replacing part of SC 43.