The highway connects the Georgia state line and the Ware Shoals area, via Antreville, Due West, and Donalds.

It begins to travel through Anderson in an east-northeast direction and then curves to the north-northwest before an intersection with SC 187.

The two highways travel concurrently to the southeast for one block, where SC 413 splits off onto East Front Street.

It starts heading east, and crosses over Lake Secession, into Abbeville County, on an unnamed bridge.

Farther to the northeast, it crosses over Turkey Creek before it meets its eastern terminus, an intersection with SC 252.