[5][6] COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus.

The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII.

This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1.

Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.

This article on a gene on human chromosome 10 is a stub.