[5][6] SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins.

Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.

[supplied by OMIM][6] A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.

[7] Recently it has been identified as a novel therapeutic target in Multiple myeloma.

[8] This article on a gene on human chromosome 1 is a stub.