SIUE College of Arts and Sciences, often referred to as CAS, is an academic college of Southern Illinois University Edwardsville located in Edwardsville, Illinois, United States.

[1] Prior to the development of the Edwardsville campus, six "Divisions of Academic Programs" were established for the SIU Residential Centers in Alton and East St.Louis on March 4, 1960.

[2] The CAS and its twenty (20) departments govern 22 undergraduate and 25 postgraduate degree programs and a large number of minor academic concentrations in the arts, humanities, social sciences, and natural sciences.

[3] The College of Arts and Sciences consists of the Departments of Anthropology, Applied Communication Studies, Art and Design, Biological Sciences, Chemistry, English Language and Literature, Environmental Sciences, Foreign Languages and Literature, Geography, Historical Studies, Mass Communications, Mathematics and Statistics, Music, Philosophy, Physics, Political Science, Public Administration and Policy Analysis, Social Work, Sociology and Criminal Justice Studies, Theater and Dance; the CAS also conducts a number of interdisciplinary programs.

[4] After construction got underway in September 2010, the project built a brand new sciences lab building that was opened in the Fall of 2013.