Opened in 2005, it is one of six pharmacy schools in Illinois and the only one located outside the Chicago metropolitan area.

It is named in recognition of the Express Scripts Foundation's multi-year support of the School.

[3] The SIUE School of Pharmacy gained international recognition when, in 2009, it organized and hosted the Strategic Planning Summit for the Advancement of Pain and Palliative Care Pharmacy with a Mayday Fund grant to "...educate and discuss the concepts of pain and palliative care and how those concepts pertains to today’s professional pharmacist."

The recommendations of the Summit were accepted in July 2010 by the American Academy of Hospice and Palliative Medicine (AAHPM).

[4] The SIUE School of Pharmacy has its offices and principal laboratories in the School of Pharmacy Lab Building in the University Park research and technology complex on the SIUE campus.