660557376ENSG00000073584ENSMUSG00000037935Q969G3O54941NM_003079NM_020618NP_003070NP_003070.3NP_065643SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.

[5][6] The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin.

The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome.

The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex.

[6] SMARCE1 has been shown to interact with Estrogen receptor alpha,[7] SMARCB1[8][9] and SMARCA4.