Sekolah Menengah Sains Kota Tinggi (English: Kota Tinggi Science Secondary School; abbreviated SAKTI) is a boarding school located in Bandar Penawar, Kota Tinggi District, Johor, Malaysia.

The school is located on an area of 50 acres and 50 km away from the town of Kota Tinggi towards Desaru, a popular tourism centre.

Work for measuring the school site was started in February 1994.

The first group of Form One consisted of 179 persons was to report to the school on 12 August 1996.

Osman b. Ahmad as a Senior Assistant Student Affairs.