Established in 1973 under the Second Malaysia Plan to comply with Malaysian New Economic Policy,[1] the school is located about a small hill in Bandar Tun Razak, overlooking the scenic Permaisuri Lake.

[3] The school continue to strive and produce great results in the public examination in the following years.

[4] Sekolah Menengah Sains Selangor is actually located within the boundaries of the Federal Territory of Kuala Lumpur, despite what its name suggests.

[6] SMSS is a co-ed school, with students from all states in Malaysia (not only catering those from the Peninsular especially the Klang Valley/Greater Kuala Lumpur area).

The school enrollement were focused mainly on excellent student from rural areas and economically disadvantage background.

[7][8][9] The pioneer batch of students which were made up of Form 1 and 4 started in 1973 temporarily placed for a year at three other different schools such as Sek.

Meanwhile, the form four students were temporarily placed in both Sekolah Sultan Alam Shah and King Edward VII School, Taiping.

[10] After more than 34 years of establishment, SMSS now stands tall and proud alongside other more established SBPs like its own fellow rivals like Sekolah Menengah Sains Tengku Muhammad Faris Petra and Sekolah Menengah Sains Raja Tun Azlan Shah.

They find themselves locking horns with each other during yearly competitions such as rugby, hockey, debate, wind orchestra and other events organized by the SBP sector of the Ministry of Education (MOE).

Needless to say, Sekolah Menengah Sains Selangor has won their fair share of these competitions, and they would have given a more than worthy challenge for their opponents.

Interestingly, the school was selected to be one of the off-site team challenge venues for MasterChef Malaysia season 2.

Situated strategically on top of a small hill in Bandar Tun Razak, Kuala Lumpur; Sekolah Menengah Sains Selangor has one of the most fascinating views overlooking the scenic Permaisuri lake.