It is located along the Jose Abad Santos Avenue (formerly Olongapo-Gapan Road) in San Fernando and Mexico in the province of Pampanga.

SM City Pampanga is located along Jose Abad Santos Avenue (formerly Olongapo-Gapan Road), corner North Luzon Expressway, Barangay San Jose, City of San Fernando, and Barangay Lagundi, Mexico.

The mall's east wing (Building 4) is located along the Jose Abad Santos Avenue, Barangay Lagundi, Mexico, Pampanga.

The mall is adjacent to both the San Fernando Exit of the North Luzon Expressway and to the Robinsons Starmills Pampanga.

The newest annex (Building 4) opened in October 2007 with an additional 16,700 square meters of floor area.