4U321065320733ENSG00000167642ENSMUSG00000074227O43291Q9WU03NM_021102NM_001166103NM_001082548NM_011464NP_001159575NP_066925NP_001076017NP_035594Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene.

[5][6][7] SPINT2 is a transmembrane protein with two extracellular Kunitz domains to inhibit serine proteases.

This gene is a presumed tumor suppressor by inhibiting HGF activator which prevents the formation of active hepatocyte growth factor.

Mutations in SPINT2 could result in congenital sodium diarrhea (CSD).

This article on a gene on human chromosome 19 is a stub.