The highway begins at SR-26 (Riverdale Road) and heads south under I-84, turning southeast at the SR-168 intersection and slowly climbing towards the end at US-89.

Traffic wanting to continue east through the canyon, leaving the Weber Valley to cross the Wasatch Range, heads north on US-89 to I-84.

[4][5] It was also along the route of the transcontinental Lincoln Highway from September 1913[6] until April 1915, when the auto trail was moved to the more direct Parley's Canyon.

[9] At the west end, a short realignment was built with federal aid as a national defense project in the early 1940s to improve access to the Ogden Ordnance Depot.

[11] State Route 49A was designated in 1953 as an effective eastward continuation of SR-60, running northeast from US-89 (legislatively SR-49) near the east end of SR-60 along what is now Cornia Drive to US-30S at the mouth of Weber Canyon.