SCAP is an integral membrane protein located in the endoplasmic reticulum (ER).

One of the cytosolic regions of SCAP contains a hexapeptide amino acid sequence, MELADL, that functions to detect cellular cholesterol.

[9] Scap has 8 transmembrane domains and both the N-terminal and C-terminal face the cytoplasm.

Also, it binds SREBP by a series of consecutive WD repeats on its C-terminus.

[10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.