The road is entirely four-lanes wide with center left-turn lanes where available, and is divided only at its eastern terminus.

From there it skirts along the southern border of Pretty Bayou where it intersects such highways as State Road 390 and later County Road 385 (Frankford Avenue), one of three routes leading north to Panama City-Bay County International Airport.

The rest of the road passes by such sites as the Gulf Coast College Seminary, Gulf Coast Medical Center, and Forest Lawn Memorial Cemetery, before entering the northeast side of the city and crossing an intersection with State Road 77, the southeast corner of which includes the Panama City Mall.

The route begins at CR 67 within Apalachicola National Forest as National Forest Highway 13, which crosses a bridge over the Ochlockonee River, and thus crosses the Liberty-Wakulla County Line.

From there it intersects CR 375 near Smith Creek, Florida, and continues to wind east through the forest.