On June 18, 1905, while sailing upbound on Lake Huron with a cargo of coal, she was rammed and sunk by the freighter Amasa Stone 10 miles (16 km) off Presque Isle Light.

[3][5][2] On June 18, 1905 while upbound with a cargo of coal from Toledo, Ohio, heading to Superior, Wisconsin, Etruria was rammed by the larger steel freighter Amasa Stone on her starboard side, abreast of her No.9 hatch.

[2][11][12] After just five minutes, Etruria rolled over and sank about 10 miles (16 km) off Presque Isle Light; her entire crew was rescued by the steamer Maritana.

The United States Court of Appeals for the Sixth Circuit rendered a final judgement on June 15, 1908.

[1] About 03:35 hours that morning on a proper course headed for the Straits of Mackinac, the Etruria heard the fog signals of a steamer, which proved to be the Amasa Stone.

The suit further stated that the collision was "due solely to the negligence and want of care on the part of Amasa Stone and those in charge of navigation".

[1] They also concluded that Amasa Stone did not leave the scene following the collision, but that she turned round, and tried to offer assistance, but Etruria's crew took to the lifeboats, and rowed off in the opposite direction.

[1][13][14] In 2011 a group consisting of expert shipwreck hunters and high school students from Saginaw, Michigan tried to locate the long sought-after semi-whaleback steamer Choctaw.

[1] Their search effort was made into a documentary named "Project Shiphunt", which was sponsored by Sony and Intel.

[1] Her forward ladder is in place running to the port side bridge wing, which is buried in sediment.

On September 19, 2014 the wreck of Etruria was nominated for a listing on the National Register of Historic Places, for her state level significance.