SUPERFAMILY is a database and search platform of structural and functional annotation for all proteins and genomes.
[1][2][3][4][5][6][7] It classifies amino acid sequences into known structural domains, especially into SCOP superfamilies.
[8][10] Superfamilies are groups of proteins which have structural evidence to support a common evolutionary ancestor but may not have detectable sequence homology.
For each protein you can: For each genome you can: For each superfamily you can: All annotation, models and the database dump are freely available for download to everyone.
Sequences can be submitted either by raw input or by uploading a file, but all must be in FASTA format.
A successful search yields the class, folds, superfamilies, families, and individual proteins matching the query.
Trees are generated using heuristic parsimony methods, and are based on protein domain architecture data for all genomes in SUPERFAMILY.
Downloads Sequences, assignments, models, MySQL database, and scripts - updated weekly.