5E5B, 4Z2M, 4Z2N11198114741ENSG00000092201ENSMUSG00000035726Q9Y5B9Q920B9NM_007192NM_033618NP_009123NP_291096FACT complex subunit SPT16 is a protein that in humans is encoded by the SUPT16H gene.

[5][6][7] Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II.

However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA.

One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation.

[7] This article on a gene on human chromosome 14 is a stub.