3MTS683920937ENSG00000101945ENSMUSG00000039231O43463O54864NM_003173NM_001282166NM_001290716NM_011514NM_001358237NP_001269095NP_003164NP_001277645NP_035644NP_001345166Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.

[5] This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain.

This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating lysine-9 of histone H3.

Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.

[6] In mouse embryonic stem cells, Suv39h1 expression is repressed by OCT4 protein through the induction of an antisense long non-coding RNA.