Safe Harbor Certified Seafood is the first brand developed under San Rafael, California based Micro Analytical Systems, Inc. (MASI).

Seafood bearing the Safe Harbor seal is tested for overall mercury content to be under the FDA's action level of 1ppm, histamine, Escherichia coli O157:H7(E.coli O157:H7) and salmonella.

In 2002, Micro Analytical Systems, Inc. (MASI) developed technology for testing seafood for its mercury concentration.

According to their data, MASI has conducted over 200,000 tests on seafood to determine its mercury concentration and presence of histamine and harmful pathogens.

MASI uses the competitive ELISA (Enzyme-linked immunosorbent assay) method for the screening of histamine in scombroid species of fish.