The Safford House is a historic home in Tarpon Springs, Florida.

On October 16, 1974, it was added to the U.S. National Register of Historic Places.

The house is named for its original owner, Anson P.K.

The city of Tarpon Springs owns and operates the Safford House Museum as a late 19th-century Victorian historic house museum.

This article about a property in Pinellas County, Florida on the National Register of Historic Places is a stub.