The domain was centered in what is now the Sagara district of Makinohara city, Shizuoka Prefecture.
The Honda were replaced by Itakura Katsukiyo, who ruled for only three years before being transferred to Annaka Domain in Kōzuke Province.
However, after Tokugawa Ieharu’s death Tanuma Okitsugu soon fell from favor, and reduced in rank and income.
However, in 1823, his son Tanuma Ogimasa was allowed to return to Sagara, where he and his descendants remained until the Meiji Restoration.
The domain maintained its primary residence (kamiyashiki) in Edo at Kanda, until the An'ei (1772–81) period, and at Hanjo at the time of the Meiji restoration.