Driven by a belief in the power of the arts to strengthen and connect communities, the Segal's programming emphasizes original interpretations of popular classics and contemporary works, new Canadian musicals, and engaging productions with universal appeal.

Bryna Wasserman) by Jon Marans was co-produced with Théâtre du Rideau Vert and played in French as Une musique inquiétante before the original cast and crew moved to the Segal to perform the production in English.

In June 2015, the Centre premiered Belles Soeurs: The Musical based on the play by Michel Tremblay with book and lyrics by René Richard Cyr, music by Daniel Bélanger, English adaptation of book and lyrics by Neil Bartram and Brian Hill, and directed by René Richard Cyr.

Its second stage, The Studio, has been a venue for SideMart Theatrical Grocery; the Power Jazz series; and the Segal’s Broadway Café events, as well as guest programming.

In addition, the Segal Centre for Performing Arts houses the Dora Wasserman Yiddish Theatre, celebrating almost sixty years of dramatizing the Jewish experience.