[7] In 1944, Saifudin participated in the Three Districts Revolution [zh] that broke out in the Ili, Tacheng and Altay regions of Xinjiang, resolutely opposing the Kuomintang's rule.

He was involved in the establishment of the Revolutionary Youth Organization in the three regions and held the positions of central committee member and head of the publicity department.

In November 1946, delegates from the three districts approached the representatives of the Chinese Communist Party and formally sought acceptance of CCP leadership.

[13][3] On October 15, 1949, Saifuddin filed his application for membership to the Chinese Communist Party, in accordance with recommendation of Mao Zedong himself[6] He joined the CCP on December 27.

The CCP Central Committee endorsed Saifuddin's proposal, leading to the establishment of the Xinjiang Uyghur Autonomous Region.

He participated in directing Xinjiang's three-year national economic recovery efforts and the execution of the nation's inaugural Five-Year Plan, contributing significantly through diligent and meticulous work towards the fulfillment of socialist transformation in Xinjiang and its swift progression to extensive socialist economic development.

Subsequent to February 1978, Saifuddin commenced employment in the Beijing and held the position of Vice Chairman of the Standing Committee of the Fifth, Sixth, and Seventh National People's Congresses.

[2] He died in Beijing on November 24, 2003, and was interred at the Revolutionary Martyrs' Cemetery in Urumqi [zh], Xinjiang Uygur Autonomous Region, in accordance with Uyghur customs.