The Saigon River (Vietnamese: Sông Sài Gòn) is a river located in southern Vietnam that rises near Phum Daung in southeastern Cambodia, flows south and southeast for about 230 km (140 mi) and empties into the Nhà Bè River, which in its turn empties into the South China Sea some 20 km (12 mi) northeast of the Mekong Delta.

The river is important to Ho Chi Minh City as it is the main water supply as well as the host of Saigon Port, with a total cargo volume loaded and outloaded of more than 35 million metric tons in 2006.

The Bình Quới Tourist Village is located on the Thanh Da peninsula on the Saigon River, in the Bình Thạnh District of Ho Chi Minh City.

The Saigon River Tunnel running under the river, connecting District 1 in the west to the Thủ Thiêm New Urban Area in the east, was opened to traffic on November 20, 2011.

Since its completion, it has been the longest cross-river tunnel in Southeast Asia.