The Gotthard Massif or Saint-Gotthard Massif (German: Gotthardmassiv or Sankt-Gotthard-Massiv; Italian: Massiccio del San Gottardo; Romansh: Massiv dal Gottard) is a mountain range in the Alps in Switzerland, located at the border of four cantons: Valais, Ticino, Uri and Graubünden.

The eponymous Gotthard Pass, lying at the heart of the massif, is the main route from north to south (excluding tunnels).

The region of the Gotthard lies at the heart of the Swiss Alps, often referred to as the "water tower of Europe".

Three major rivers take their source in the Gotthard Massif: the Reuss, Rhine and Ticino.

A fourth river, the Rhône, takes its source in very close proximity of the massif, just north of the Furka Pass.