Saint-Simon-les-Mines (French pronunciation: [sɛ̃ simɔ̃ le min]) is a municipality in the Municipalité régionale de comté de Beauce-Sartigan in Quebec, Canada.

It is part of the Chaudière-Appalaches region and the population is 573 as of 2021.

It is named after Simon the Zealot, one of Jesus' apostles, while "les Mines" refers to a small gold mine that was discovered and exploited in the mid-nineteenth century.